exaggeration much?
I have fired my weapons with no hearing protection before, magically my brain didn't ooze out of my ears. The only distracting percussion I have seen is when I am at the range and someone pulls out a .44 mag or .50. Then I am in my own world and hear : pop, pop, pop pop. pop pop. KABOOM, pop pop pop KABOOM. .38-.45 yeah I notice a difference between reports, but nothing like a big magnum.
A weapon intended for defense should be a DEFENSE caliber, .22 is NOT a defense caliber, and the ~100lb women I know who carry, carry .38 or .380. PPK style or Snubby revolver. Easily controlled by dainty hands. Putting a .22 in someones hands for "defense" is not an effective practical or reliable means of defense. I'm not saying that someone the size of mary kate and ashley olsen should carry around a .45, but a .32 would be sufficient.