depending what time you're going different freeways are best I take this route couple times a week to school (I work at DeSoto and 101). Anyways take 101 to 5 S to 91E exit Harbor Blvd (go north) and it will be on your right hand side.
You could alternatively take 405S to 91E but 405S coming down towards Getty and then towards Santa Monica Blvd and then again around airport is a major PITA. 5S might be crowded all the way through but it will move pretty steadily. http://www.inandout.com/cgi-bin/inosearch.pl?category=store&data_in=77