Tyler - if it will benefit you guys more in the long run to move, do it. Your wife will come around, she is probably just settled into where you are now.
For example, my academic advisor notified me that Virginia is currently hiring for the job I am in school for. They don't require a 2 year degree like Indiana does, and he encouraged me to apply. I told the wife, and she was instantly opposed. The more we talk about it the more she is coming around. I am going to apply just to see what happens; if it goes somewhere then we will talk seriously about it, but if not, then at least I tried. I would rather give it a shot and not make it than not try at all and regret it later.
Just my $0.02.