Yes. 5 on 4.5 bolt pattern. I'm currently looking at doing this (I have an 8.8 with 4.10s and discs sitting in a friend's garage right now, and a flange yoke adapter sitting on my passenger seat in the parking lot at work...) and here is some info I have dug up:
http://www.naxja.org/forum/showthread.php?t=1000520
http://www.jedi.com/obiwan/jeep/ford88.html (he talks about doing it in a YJ, but a lot of the info is the same)
http://members.cox.net/rough-riders/tech_page/ford8.8/ford8_8.html (another YJ page, more info!)
http://forums.off-road.com/jeep-short-wheelbase/117239-ford-8-8-spicer-2-2-1379-they-yard.html (info about the flange yoke adapter you will need)
http://www.alljeep.com/oscommerce/product_info.php?manufacturers_id=537&products_id=167208 (cheapest I can find the dana 2-2-1379 flange yoke adapter new)
My own info:
* You can get a dana 2-2-1379 flange yoke for 1310 U-joints for $10 or so at most junkyards, they are found in Mercury Grand Marquis with a 7.5 or 8.8 rear end. Bring a 12mm 12-point socket, a 3/8 ratchet, an extension bar, a breaker bar, a can of pb-blaster, a mini torch if you can (i.e. smuggle it in. You will need it.) Also useful is a sawzall with a 9" metal cutting blade, unless you want to buy the whole rear driveshaft along with it and pop the u-joint out of the adapter afterwards - I just cut the driveshaft. You'll want a good 2-3ton jack as well if the junkers aren't on blocks at your JY. Jack the sucker up, apply the mini torch to the flange and end of the bolt for a minute or two, use your breaker bar, move to the next bolt. Once the bolts are out chop the driveshaft and whack the flange/ujoint/whatever else with your breaker bar till the flange pops off the differential.
* get the spring pads when you take the 8.8 out of the explorer or whatever, just sawzall the shock mounts off, you won't need them and it is faster than pulling the bolts.
* I've been told you will need a different rear driveshaft since the pinion length is different on the 8.8, I need to measure stuff and figure out what I'm doing about that.
MoparManiac told me about the flange being found on a Grand Marquis - one of the local guys up here has an 8.8 in his rig so he found out. Alternatively you can just use a 1310 to 1330 adapter U-joint and use the flange that you (hopefully) think to get with the 8.8.