Not a problem. I've been running a 4.6L stroker in my '92 XJ with AX15 5-speed for the last nine months and 9700 miles without any issues.
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Dino's "Mean Green Machine" 1992 XJ Laredo 4-dr - 4.6L I6 HO Stroker - 184k miles - AX15, NP231, D35c, D30
Not too many hard launches, but then the wheels spin all too easily so not all of the power is getting to the ground. Might be a different story if I had better traction but still with 2WD.
Full-time 4WD would spread the torque to all four wheels and reduce the load on the rear axle.