I would think the s-10 would need to have a high stall torque converter to take advantage of such a big turbo. I don't know the size of a Duramax turbo, but it has to be quite a bit bigger than even a factory Typhoon/Syclone turbo, which is sized to come on around 1800-2000rpm.
I had a Typhoon too, and put a bigger turbo on it, among many other mods. Also swapped in a 2800rpm stall TC. Was VERY quick.... and VERY scarey to drive in 2wd, especially on wet roads. I broke the front prop shaft smoking all four tires, and spent 2 weeks smoking the rear tires in that truck.... Could kick it down into passing gear rolling along at 40-50mph, and smoke the rear tires. It was a fun two weeks!