IHO if you can fit bigger tires, DO IT. My buddy has a Flipped 60 in the rear with 35 boggers and my other friend has 35 boggers but with the 44. everyplace the 60 gets caught up on the 44 goes right over.
Back to the gearing though, is it a DD or trail only? if its a trail yea like Beezil said, id do a 5.38. if it both a dd & trail id do like a 4.88 maybe 5.13