I think there's a difference between maximizing your mileage and realizing the limitations of the vehicle you're driving.
Let's say for arguement's sake that you get 16 mpg daily driving. We're not talking taking a long trip with the cruise on, just your average get you to work and back and around town and back home. If you're like me and you live 20 miles from work (mostly highway) it's pretty balanced between acceleration and cruising.
So you get 16, times about 17 gallons (because nobody runs the tank dry) is 272 miles. Right now, gas at my house is 2.49 a gallon. So to fill that tank back up, you're going to spend 42.48. That's 6.4 miles per dollar, if you're keeping track of that sort of thing.
Let's say you really baby it (and spend the money on a vacuum gauge, which is another conversation) and get 18 mpg. Again, let's be realistic about where we're driving. That's 306 miles. So on that 42.48 you're going to spend to fill up, you're getting 7.2 miles per dollar.
Now if you're me and you drive 40 miles round trip, 5 days a week, 50 weeks a year (for arguement's sake) you're driving 10,000 miles a year. At 18 mpg, you're going to spend 1388.89 on gas. At 16 mpg, you're going to spend 1562.50.
So for the constant attention and focus that what you're suggesting requires, you saved $173.01 for the YEAR. I spend more than that on lunch in a month.
I guess if it's worth it to you, pay attention to it. I can't justify the work it would take to save what amounts to 14.47 a month. I'd rather just drive and enjoy myself.