I've lost about 6mpg myself (1988 4.0 5sp) for no good reason I can find - and my wife has dropped 4-5mpg, although I've not been able to do her tuneup lately. Smog numbers on both vehicles (just before the beginning of the year) were excellent, so I know they're running their fuel well.
Woody - for more info on MTBE, do a search. There's a lot out there, this stuff is mildly toxic in ppb, and is harder than the hinges of Hell to get out of groundwater. Contamination (IIRC) is caused by spills, seepage from ground tanks, and from exhaust from engines running MTBE-laced fuel.
MTBE was originally mandated for ReFormulated Gasoline (RFG) as an oxygenator to reduce winter emissions while engines were getting to operating temperature, but has been shown to have no beneficial effect of any sort - much less for its intended purpose. The addition of ethanol in its place is a compromise measure, butis an improvement, as ethanol is itself a fuel (though considerably less energetic than gasoline, unless engines are retuned to run on it.)
Frankly, start by going from a "methods-based" means of reducing tailpipe emissions to a "results-based" methodology, and allow gearheads to start deleting the devices that really don't help, and tune engines for peak efficiency, rather than stick with the useless, failure-prone parts. But I'm cranky...
5-90