Given the low base compression (both static and dynamic) of the 4.0 engine, why are you worried about octane boosts? Typically, you need to boost octane if you're getting knock from detonation/preignition (which can be caused by hot spots combined with a fuel that is too volatile for the mix,) and reduction of fuel volatility (the octane increase) will help to prevent that.
If you're getting a preignition/detonation problem with a 4.0, and you're not running forced induction and haven't gotten silly with moving the IVC event on your cam, you've got deeper issues and should check out the chambers anyhow (borrow a fibrescope and pull the plugs - look around through the plug holes.) If you have a lot of carbon in there, you can start trying to remove it using the "water trick" I've described here several times over.
If that doesn't work, you'll end up pulling the head and taking a brass wheel brush to it to clear the carbon out, and I'd take a Cratex kit to it while I had it off to present a smooth surface inside the combustion bowl, and make sure to break any sharp edges I found while I was in there. This will reduce/eliminate any hot spots that are there under operation, and will help with the preignition/detonation.
I've spent a lot of time playing with ignition timing, fuel mixes, cam/valve timing, and I've even gotten into exotic fuels, so I've got a little experience at this. I've been in school working on refresher knowledge/new knowledge, and my current degree track will make me an automotive mechanical engineer by the time I'm done.
I'll agree that power can be found in odd places, but I'll also say that fuel/ignition tuning won't free up everything. The engine has to be taken as an entire system - I've usually started by selecting a camshaft and a fuel, and working forward from there. While my exotic fuel notebooks aren't in the same state as me anymore, there are a few things I might still recall on alky engines, and I've been doing a lot of fuel research lately for an update to my book...
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